The aim of the school is to present the different methods of analysing molecular dynamics, illustrated by the most advanced studies ranging from the determination of very fast internal motion in macromolecules to the observation of the slow folding process of proteins. These analyses also consider the biological activity of the protein. The implications of dynamics for the determination of three-dimensional structure will also be developed. The topics that will be covered during the school fall into three broad categories: 1) basic methods for studying macromolecular dynamics; 2) combinations of biological and physical methods and implications of dynamics; 3) studies of specific systems. NMR has reached a stage where both three-dimensional structure and dynamics can be studied quite accurately. An integrated approach between these two aspects should be increasingly used in future research. The proposed school should bring together the interesting features of such an integrated approach.